The Effect of Plasma Osmolality on Brain Glutamate

Phase 1

Completed

• Conditions: Schizophrenia
• Interventions: Drug: furosemide, Na supplements

• Registration Number: NCT00611741
• Lead Sponsor: Yale University

Brief Summary

This study is designed to test the hypothesis that plasma osmolality is linked with cortical glutamate concentrations in the brain. It also investigates whether the glutamate response in schizophrenia is enhanced compared to healthy controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2008-01-29
• Study First Submitted QC: 2008-02-08
• Study First Posted: 2008-02-11
• Primary Completion: 2011-03
• Study Completion: 2012-03
• Status Verified: 2012-08
• Last Update Submitted: 2016-02-06
• Last Update Posted: 2016-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Drug intervention, longitudinal	furosemide, Na supplements	Furosemide and Na supplements

Primary Outcome Measures

Name	Time	Method
Cortical glutamate concentration	Baseline and endpoint

Secondary Outcome Measures

Name	Time	Method
Cognitive function	Baseline and end point

Trial Locations

Locations (1)

34 Park Street, CMHC; 🇺🇸 New Haven, Connecticut, United States