NCT01644942已完成不适用
Identification in Obese Patients of the Mechanisms Involved in Intramuscular Lipid Accumulation.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- lipid accumulation in skeletal muscle
研究概览
简要总结
The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.
详细描述
Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2
- •Patients who do not practice physical exercise (Voorips index < 9)
- •Age between 40 and 70 years- Male gender
- •Fast blood glucose <1,10 g/l and no hypoglycemic treatment
- •Signed informed consent
- •Social security affiliation
- •Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen
- •Normal biological tests
- •Non smoking persons
排除标准
- •Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests
- •Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory.
- •Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy
- •Allergy to local anaesthetic
研究组 & 干预措施
Insulin sensitive patients
Other
干预措施: Lipid accumulation analysis (Other)
Insulin resistant patients
Other
干预措施: Lipid accumulation analysis (Other)
结局指标
主要结局
lipid accumulation in skeletal muscle
时间窗: 1 month
次要结局
- lipid accumulation in myotubes from obese patients(1 month)
研究者
研究点 (1)
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