Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue
- Registration Number
- NCT01845363
- Lead Sponsor
- Universidade Federal de Pernambuco
- Brief Summary
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at the beginning and end of surgery, were analyzed using high performance liquid chromatography.
Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection.
To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
- body mass index greater than 35 and less than 50kg/m2
Exclusion Criteria
- Hypotension during surgery with use of vasoactive drugs
- renal disfunction (creatinine >1.5 mg/dL)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cefazolin Cefazolin used in antimicrobial prophylaxis Cefazolin used in antimicrobial prophylaxis Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours. Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis. The samples were processed by High Pressure Liquid Chromatography (HPLC).
- Primary Outcome Measures
Name Time Method dosage of Cefazolin in adipose tissue during bariatric surgery eight months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Universidade Federal de Pernambuco - Hospital das Clínicas
🇧🇷Recife, Pernambuco, Brazil