Prepubertal insulin sensitisation in girls with a combined history of low birthweight and precocious pubarche
Completed
- Conditions
- Precocious pubarcheUrological and Genital Diseases
- Registration Number
- ISRCTN84749320
- Lead Sponsor
- Hospital Sant Joan de Deu (Spain)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 38
Inclusion Criteria
Girls with a combined history of low birthweight (less than 1.5 standard deviation score [SDS]) and precocious pubarche (appearance of pubic hair before age 8)
Exclusion Criteria
1. Congenital adrenal hyperplasia
2. Diabetes mellitus
3. Thyroid dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Onset of puberty, measured at baseline and every 6 months (timepoints added 11/07/2008)
- Secondary Outcome Measures
Name Time Method 1. Menarche, measured baseline and every 6 months. All untreated girls are already menarcheal, 14 of 19 treated girls are mernarcheal.<br>2. Final height, measured end of the 6th year<br><br>Timepoints added 11/07/2008