Insulin sensitisation in post-menarcheal girls with a history of low birthweight and precocious pubarche: effects of the addition of antiandrogen treatment and of the androgen receptor length on body composition and endocrine-metabolic parameters

Completed

• Conditions: Ovarian hyperandrogenism; Urological and Genital Diseases

• Registration Number: ISRCTN08608368
• Lead Sponsor: Hospital Sant Joan de Deu (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-05
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

1. Post-menarcheal state
2. A history of low birthweight and precocious pubarche
3. Subclinical ovarian hyperandrogenism
4. Hyperinsulinemia

Exclusion Criteria

1. Clinical signs of androgen excess
2. Family or personal history of diabetes mellitus
3. Late-onset congenital adrenal hyperplasia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Development of clinical hyperandrogenism<br>2. Body composition

Secondary Outcome Measures

Name	Time	Method
1. Decrease of androgens<br>2. Improvement of insulin sensitivity