Evaluation of the Impact of Pancreatectomy on Systemic Immunity

Not Applicable

• Conditions: Pancreatectomy; Hyperglycemia; Pancreas Cancer
• Interventions: Other: Blood sampling

• Registration Number: NCT03978702
• Lead Sponsor: Institut Paoli-Calmettes

Brief Summary

The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy. Blood samples will be collected before surgery, (Day-1), at day0, and after surgery at Day 1, Day 3, Day 7 at 1 year after pancreatectomy. Mass cytometry, genomic and transcriptomic approaches will be used to evaluate the immune systemic modulation after surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-03
• Study First Submitted QC: 2019-06-05
• Study First Posted: 2019-06-07
• Study Start: 2021-02-24
• Status Verified: 2021-05
• Last Update Submitted: 2022-01-05
• Last Update Posted: 2022-01-06
• Primary Completion: 2022-07-27
• Study Completion: 2022-07-27

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patient with an indication of pancreatectomy
• Signed consent form

Exclusion Criteria

• Neoadjuvant treatment
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Indication for pancreatectomy	Blood sampling	Blood sampling at different time points before and after pancreatectomy

Primary Outcome Measures

Name	Time	Method
Measurement of immune effectors (Tcells, NK) levels after pancreatectomy	1 year	Evaluation of immune effectors my mass cytometry after pancreatectomy (compared to baseline)

Trial Locations

Locations (1)

Institut Paoli Calmettes; 🇫🇷 Marseille, France