Effect of thoracolumbar muscle plane block on postoperative pain and inflammation in spine surgery patients.
Phase 3
- Conditions
- Health Condition 1: G544- Lumbosacral root disorders, not elsewhere classifiedHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/08/072070
- Lead Sponsor
- Ruchi Verma Department of Anaesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients who will give consent, ASA Physical status I or II, Scheduled for lumbar spine surgery
Exclusion Criteria
Patients with allergy to local anaesthetic, Coagulaton disorder, Infection at injection site, Chronic NSAID or opioid use, BMI more than 30 Kg/m2, Patients with neuromuscular disorder, Patients having chronic inflammatory disease, Patients with pre- existing autoimmune diseases
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-operative pain assessment as per Visual analog scale (VAS) score.Timepoint: VAS score at 1, 6, 12, 24 and 48 hours in postoperative period in both the group.
- Secondary Outcome Measures
Name Time Method 1. Variation in Serum levels of IL-1, IL-6, IL-4 and IL-10 <br/ ><br> <br/ ><br>2. Total Intraoperative opioid consumption, <br/ ><br> <br/ ><br>3. Postoperative rescue analgesia requirement <br/ ><br>4. Postoperative nausea and vomiting <br/ ><br> <br/ ><br>5. Time to hospital discharge. <br/ ><br>Timepoint: 1. At baseline, 6 hours, 24 hours and 48 hours <br/ ><br> <br/ ><br>2. At the end of surgery <br/ ><br> <br/ ><br>3 & 4. 1 hour, 6 hours, 12 hours, 24 hours and 48 hours <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br>