An assessment of arterial stiffness, oxidative stress and inflammation in acute kidney injury

Not Applicable

Recruiting

• Conditions: Acute kidney injury; Renal and Urogenital - Kidney disease; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12609000285257
• Lead Sponsor: Royal Brisbane and Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-05-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Creatinine >133 umol/l or urea > 14.3 mmol/l or oliguria with urine output < 410 ml/day

Exclusion Criteria

Already receiving dialysis or hemofiltration
Receiving ionotropic agents

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aortic stiffness will be measured with aortic pulse wave velocity in m/sec measured with a Sphygmocor device[Baseline and 6 and 12 months after the onset of the acute kidney injury]

Secondary Outcome Measures

Name	Time	Method
oxidative stress measured with F2 isoprostanes (blood measure)[Baseline and 6 and 12 months after the onset of the acute kidney injury];Inflammation measured with pentraxin-3 (blood measure)[Baseline and 6 and 12 months after the onset of the acute kidney injury]