Health Effects of Oat and Oat Polar Lipids in Human
- Conditions
- Postprandial Glucose Regulation
- Interventions
- Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables
- Registration Number
- NCT05139355
- Lead Sponsor
- Lund University
- Brief Summary
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
- Detailed Description
The overall goal is to increase the knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on cardiometabolic test markers of oat and oat based product. The new knowledge will form a base for the development of oat based food products with added health values.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Healthy adults
- BMI 18.5 - 28 Kg/m2
- Non smokers
- Consuming a non-vegetarian diet that follows the Nordic diet recommendation.
- Fasting blood glucose concentration >6.1 mmol/l
- Known cardio-metabolic disease (e.g. diabetes, hypertension, metabolic syndrome).
- Gastro-intestinal disorders such as IBS (irritable bowel syndrome) that can interfere with the study results, food allergies.
- No antibiotics or probiotics should have been consumed within 4 weeks prior to and during the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Oat product 2 Effects of Oat and Oat Components on Cardiometabolic risk variables The test portion is based on 50 gram available carbohydrates with added vegetable oil B. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. Oat product 1 Effects of Oat and Oat Components on Cardiometabolic risk variables The test portion is based on 50 gram available carbohydrates with added vegetable oil A. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. Oat product 3 Effects of Oat and Oat Components on Cardiometabolic risk variables The test portion is based on 50 gram available carbohydrates with added vegetable oil C. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. Control Product Effects of Oat and Oat Components on Cardiometabolic risk variables The test portion is based on 50 gram available carbohydrates without added vegetable oil.
- Primary Outcome Measures
Name Time Method Blood glucose regulation 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 5.5 hours after consumption of test products.
- Secondary Outcome Measures
Name Time Method Plasma PYY (peptide tyrosine tyrosine) 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Gastro-intestinale hormones involved in appetite and metabolic regulation
Serum insulin 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Acute effects of postprandial serum insulin concentrations (incremental area under the curve) after intake of the test products.
Serum triglycerides 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Cardiometabolic risk markers
Serum Free Fatty Acids 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Cardiometabolic risk markers
plasma GLP-1 (glucagon-like peptide-1 ) 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) Gastro-intestinale hormones involved in appetite and metabolic regulation
Trial Locations
- Locations (1)
Food Technology, engineering and Nutrition, LTH, Lund University
🇸🇪Lund, Sweden