HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes

Completed

• Conditions: HIV Infection; MDR-TB

• Registration Number: NCT06671808
• Lead Sponsor: Zahedan University of Medical Sciences

Brief Summary

This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-15
• Primary Completion: 2024-08-22
• Study Completion: 2024-09-03
• Status Verified: 2024-11
• Study First Submitted: 2024-11-01
• Study First Submitted QC: 2024-11-01
• Last Update Submitted: 2024-11-01
• Study First Posted: 2024-11-04
• Last Update Posted: 2024-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 222128

Inclusion Criteria

• Adults (aged 18 years and older) diagnosed with both HIV and multi-drug-resistant tuberculosis (MDR-TB).
• Studies published in peer-reviewed journals.
• Studies that provide data on the co-occurrence of HIV and MDR-TB.
• Participants from diverse geographical regions to enhance generalizability.
• Studies with clear definitions of MDR-TB according to WHO guidelines.

Exclusion Criteria

• Studies that focus solely on drug-susceptible tuberculosis without MDR-TB.
• Studies involving pediatric populations (under 18 years of age).
• Non-original research such as reviews, editorials, and commentaries.
• Studies lacking sufficient data on the co-occurrence of HIV and MDR-TB.
• Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients	Data collected over the course of the studies from 2006 to 2018.	This study aims to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among patients co-infected with HIV. Data will be collected from various studies included in the meta-analysis, focusing on the incidence rates of MDR-TB in this population. The analysis will provide insights into the challenges faced in treating HIV-positive individuals with MDR-TB and highlight the need for targeted interventions.

Trial Locations

Locations (1)

Zahedan University of Medical Sciences; 🇮🇷 Zahedan, Sistan and Baluchestan, Iran, Islamic Republic of