Cohort of Optimized Assessment Strategy of Carotid Artery Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- death
研究概览
简要总结
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.
The main questions it aims to answer are:
- Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion.
- Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques.
Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram;
- •patients received carotid endarterectomy at Peking Union Medical College Hospital
排除标准
- •(1) Any contraindication to image examination; (3) refuse to sign the Informed consent.
结局指标
主要结局
death
时间窗: During hospital stay, usually 7-30 days post operation
perioperative death
stroke
时间窗: During hospital stay, usually 7-30 days post operation
perioperative stroke
cerebral hyperperfusion syndrome
时间窗: During hospital stay, usually 7-30 days post operation
perioperative cerebral hyperperfusion syndrome
cardiac infarction
时间窗: During hospital stay, usually 7-30 days post operation
perioperative cardiac infarction
transient ischemic attack
时间窗: During hospital stay, usually 7-30 days post operation
perioperative transient ischemic attack
次要结局
- Image characters of PET/MRI(half year after operation)
- Image characters of ultrasound(half year after operation)
- Image characters of MRI(half year after operation)
- Carotid plaque characters(half year after operation)