Clinical study of autologous tumor lysate-pulsed dendritic cell therapy for advanced colorectal cancer (Stage3, 4)
Phase 1
- Conditions
- colorectal cancer (Stage3, 4)
- Registration Number
- JPRN-UMIN000005929
- Lead Sponsor
- Tomishiro Central Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who have: (1)Pulmonary fibrosis or interstitial pneumonia, or history or predisposition of them (2)Serious drug allergy (3)Serious cardiac disease (4)Active autoimmune disease (5)Other cancers (6)Drainage is necessary (pleural/ascites effusion ) (7)Brain metastasis with symptoms (8)Edema which needs treatment (9)Positive for HIV or HTLV-1 (10)Continuous systematic administration of steroids within 4 weeks (20mg or more on a predonine conversion basis) (11)Uncontrollable infection (12)Pregnant or lactating (13)Gelling of plasma, cryoglobulinemia (14)Any reason why, in the opinion of the investigator, the patient should not participate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Safety
- Secondary Outcome Measures
Name Time Method Immunological responses Antitumor effect progression-free survival event-free survival overall survival