Cerebral imaging in adults with sickle cell disease using ultra high field magnetic resonance imaging
Completed
- Conditions
- stroke100189021000533010007963
- Registration Number
- NL-OMON36437
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
patients with sickle cell disease
treated at AMC
aged 18-25
Exclusion Criteria
Overt stroke, defined as a focal neurological deficit with either motor or sensory deficit lasting more than 24 hr or focal neurological deficit lasting less than 24 hr with neuroimaging evidence of a cerebral infarct corresponding with the focal deficit.
Chronic blood transfusion schedule.
The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves).
Claustrophobia.
Surgery performed in the area of measurement in the last 3 months.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint is the presence of (pre-) pathological changes of brain<br /><br>parenchyma, blood vessels or other intracranial structures at 7.0 Tesla MRI.<br /><br>Intracerebral changes include cystic infarction, atrophy, encephalomalacia,<br /><br>leukoencephalopathy or changes of the intracerebral blood vessels. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Demographical and clinical patient characteristics including age, HbS<br /><br>phenotype, Hb, HbF, leukocytes during stable clinical state, presence of<br /><br>epilepsy.<br /><br>Cerebral blood flow asymmetry, defined as previously described by Van den Tweel<br /><br>et al.<br /><br>Neurological examination.<br /><br>Verbal IQ, performance IQ and full scale IQ, and visuo-motor functioning. </p><br>