Cerebral Perfusion Imaging in Children with Sickle Cell Disease

• Conditions: Hereditary anemia; 10007963; Sickle cell disease; 10038158; 10027664

• Registration Number: NL-OMON33195
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

35 children with sickle cell disease aged between 8 and 20 years, without history of symptomatic infarction and 15 age-matched controls without SCD

Exclusion Criteria

The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia; surgery performed in the area of measurement; known or symptomatic brain infarction; already on chronic blood transfusion schedule.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Whole brain and regional CBF measured by ASL at 3T MRI (ml/100g/min).<br /><br>Neurological and neuropsychological findings.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Regional arrival time of arterial blood as measured by ASL (ms).</p><br>