ovel diagnostic strategies in children with sickle cell disease: detecting pulmonary hypertension; a pilot study

Recruiting

• Conditions: HbSC); HbSS or compound heterozygous sickle cell disease (HbSbetathal; sickle cell disease; 10018902

• Registration Number: NL-OMON31852
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Sickle cell patient, 12 to 18 years of age.

Exclusion Criteria

Acutely or critically ill patients, recent bloodtransfusion (< 3 months prior), not able to understand Dutch adequately.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlations between echocardiographic results (tricuspidalis Regrurgitant Jet<br /><br>Velocity Value; m/s) and FeNO at different expiratory flow velocities will be<br /><br>tested, in order to evaluate the predictive value of exhaled NO in diagnosis of<br /><br>PH. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Evaluation of possible (genetic) risk factors for pulmonatry hypertension in<br /><br>SCD</p><br>