Assessing and comparing efficacy of cyclosporine versus azathioprine in CR
- Conditions
- Health Condition 1: null- Satisfactory
- Registration Number
- CTRI/2017/08/009213
- Lead Sponsor
- il
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
chronic spontaneous urticaria, with disease duration of at least 6 months or above, which is not controlled with four fold increased dosage of antihistamines (as per EAACI guidelines), given for at least three consecutive months and requiring repeated courses of oral corticosteroids. There is no strict number of oral corticosteroids intake courses before the patient can be labeled as chronic refractory urticaria.
1. Patients giving history of fainting, bronchospasm during previous attacks of urticaria that is suggestive of anaphylaxis.
2. Urticaria < 6 weeks.
3. Age <18 years.
4. Physical and pressure urticaria.
5. Urticarial vasculitits.
6. Pregnant and lactating patients.
7. Cataract, hepatic or renal diseases, severe infections,poorly controlled hypertension
8. Concomitant intake of drugs like nephrotoxic drugs (gentamycin, vancomycin, amphotericin-B, indomethacin, diclofenac, H2 antihistamines like ranitidine, cimetidine, phenobarbitone, rifampicin, allupurinol, febuxostat).
9. History suggestive of allergy to azathioprine , cyclosporine.
10. Absolute contraindications69 of azathioprine are severe infections, severly impaired hepatic or bone marrow function, pancreatitis, live vaccines, pregnancy and lactation.
11. Patients with chronic kidney disease, uncontrolled hypertension, renal insufficiency,
uncontrolled infections, cutaneous T-cell lymphoma, including mycosis fungoides, should
not be given Cyclosporine70.
12. Patients who are planning pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method