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Clinical Trials/CTRI/2022/04/041778
CTRI/2022/04/041778Not yet recruitingNot Applicable

To study incidence and evolution of cardiovascular changes in Mucor mycosis infection at a tertiary care centre in North India

All India Institute of Medical Science Bathinda1 site in 1 country200 target enrollmentStarted: April 15, 2022Last updated:

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Enrollment
200
Locations
1
Primary Endpoint
Total cardiovascular events in the group

Study Overview

Brief Summary

Mucormycosis is an invasive fungal infection . In immunocompromised patients they cause vascular invasion and infarction of organs. Cardiac involvement in the form of myocarditis, angio invasive mucormycosis causing acute coronary syndrome has been reported. We planned an observational study to find out incidence and range of cardiovascular involvement in mucormycosis patients. We take both retrospective and prospective data. We do baseline ECG , echocardiography , cardiac biomarkers and  follow them up for 3 months post hospitalisation. We look for any cardiovascular involvement , acute coronary syndrome , arrhythmias during hospitalisation and follow up.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
18.00 Year(s) to 80.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • age greater than 18 years nucor cases reporting to cardiology out patient department valid informed consent.

Exclusion Criteria

  • not giving consent.

Outcomes

Primary Outcomes

Total cardiovascular events in the group

Time Frame: 4 weeks after presentation

Secondary Outcomes

  • Incidence of acute myocardial events in Mucormycosis population 
at baseline and during hospital stay(30 days)
  • Myocarditis or myocardial infarction or stenosis detected with ST segment elevation or depression associated with troponin elevation and echocardiography(30 days post hospital admission)
  • Characterization of inflammation on cardio-vascular outcomes(30 days post hospital admission)
  • New onset cardiac arrhythmia(30 days post hospital admission)

Investigators

Sponsor
All India Institute of Medical Science Bathinda
Sponsor Class
Government medical college

Study Sites (1)

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