Prognosis of a First-Ever Stroke in Persons Living With HIV

Terminated

• Conditions: Cerebrovascular Accident, Acute; HIV
• Interventions: Other: stroke center referral

• Registration Number: NCT02748252
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

With aging of the persons living with HIV, cardiovascular diseases now account for substantial mortality and morbidity. Stroke frequency grows exponentially with aging and its incidence doubles every decade over 55 years of age.

The prognosis of ischemic stroke depends mainly on the care in Stroke Units in the acute phase of the disease (thrombolysis/thrombectomy). It is important that HIV patients are referred to these units in the first hours of a stroke and not to their infectious disease units which is a loss of chance.

It would also be important to know whether HIV patients need specific protocols for stroke emergency management.

The study aims to compare the functional prognosis after the first occurrence of an ischemic stroke, in patients admitted to a Stroke Unit, whether they are infected or not infected by HIV.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12
• Primary Completion: 2015-12
• Study First Submitted: 2016-04-18
• Study First Submitted QC: 2016-04-19
• Study First Posted: 2016-04-22
• Study Completion: 2016-12
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-08
• Last Update Posted: 2018-08-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• Patients unexposed to HIV: HIV-1 seronegative OR patients exposed to HIV: HIV seropositive for over 6 months with or without antiretroviral treatment. Confirmed by Elisa and Western blot tests
• admitted for ischemic stroke, defined as a sudden cerebrovascular event confirmed by MRI
• at least 18 years of age
• paired with patients unexposed to HIV, admitted for ischemic stroke, same gender and age

Exclusion Criteria

• antecedents of a symptomatic ischemic or hemorrhagic cerebrovascular event
• no social security benefits;
• Absence of signed informed consent for the study
• Patients currently pregnant or breast-feeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non HIV patients	stroke center referral	non HIV patients admitted in Stroke units for the first occurence of acute stroke
HIV patients	stroke center referral	HIV patients admitted in Stroke units for the first occurence of acute stroke

Primary Outcome Measures

Name	Time	Method
degree of disability measured with the modified Rankin Scale	3 months

Trial Locations

Locations (1)

Fondation Ophtalmologique Adolphe de Rothschild (FOR); 🇫🇷 Paris, France