The preoperative oral caffeine for the prophylaxis against spinal anesthesia induced hypotension in patients undergoing orthopedic lower limb surgery: A randomized controlled study

Phase 1

Recruiting

• Conditions: Circulatory System; Orthopaedics; Anaesthesia

• Registration Number: PACTR202311786558285
• Lead Sponsor: Mansoura university hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-11-06
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1- Patients of both sexes aged 18 to 45 undergoing lower limb orthopedic surgery using spinal anesthesia.
2- Height from 160 cm to 180 cm.
3- American Society of Anesthesiologist physical status I, II or III.

Exclusion Criteria

1.Patients who refuse to participate in the study
2.Elevated BP (>160/100 mm Hg)
3.Failed spinal anesthesia
4.Patients with known cardiovascular disease
5.Patients with known cerebrovascular disease
6.Patients with known neurological, neurodegenerative or psychiatric disease
7.Patients with known liver failure
8.Clinical history of diabetes
9.Contraindication to spinal anaesthesia e.g. coagulopathy, H
10.Patients with known caffeine or coffee allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to investigate the efficacy of prophylactic preoperative caffeine in preventing spinal anesthesia-induced hypotension

Secondary Outcome Measures

Name	Time	Method
the total amounts of rescue ephedrine and atropine and the incidences of nausea/vomiting requiring treatment between the groups. The incidence of post dural puncture headache and postoperative delirium will be recorded.