An Iodine Balance Study to Investigate the Recommended Iodine Intake in an Elderly Population
- Conditions
- Nutrition, Healthy
- Interventions
- Behavioral: Restrict subjects' intake of iodine-containing foods
- Registration Number
- NCT06218043
- Lead Sponsor
- Wenxing Guo
- Brief Summary
Current Chinese dietary iodine reference intake (DRIs) standards lack direct data on recommended iodine intake (RNI) in the elderly. The elderly have a high prevalence of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. Identifying the appropriate iodine intake for the elderly to maintain optimal thyroid function to reduce the burden on medical resources is a public health issue requiring high attention. The iodine balance study is an important method for exploring physiological iodine requirements. Few iodine balance studies have been conducted in the elderly. This study aimed to conduct an iodine balance study and provide information on the appropriate iodine intake level for elderly people.
- Detailed Description
The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
- aged 18 and above;
- at least 5 years of local residence.
- family genetic diseases；
- special dietary habits；
- taking iodine-containing drugs or supplements；
- metabolic diseases;
- thyroid diseases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Iodine intake intervention balance experiment Restrict subjects' intake of iodine-containing foods Replace subjects' iodized salt with non-iodized salt.
- Primary Outcome Measures
Name Time Method Iodine excretion Each phase of the iodine balance study lasts 4 to 10 days. Daily iodine excretion includes urinary iodine excretion and fecal iodine excretion.
Iodine intake Each phase of the iodine balance study lasts 4 to 10 days. Daily iodine intake includes dietary iodine intake and drinking water iodine intake.
- Secondary Outcome Measures
Name Time Method thyroid function indexes Within one week before the start of the experiment. FT3、FT4、TSH、TPOAb、TGAb. Each subject was asked to collect venous blood twice (before the experiment and within one week after the intervention) to measure indicators of thyroid work.
salivary iodine 4 to 10 days Every time the subject urinates, 2ml of saliva is collected.
blood pressure Within one week before the start of the experiment. Subjects had their blood pressure measured before and after the study.
thyroid volumn Within one week before the start of the experiment. Thyroid volume was measured using thyroid B-ultrasound.
fasting blood glucose Within one week before the start of the experiment. Subjects had their fasting blood glucose measured before and after the study.
Trial Locations
- Locations (3)
Gansu provincial center for disease control and prevention
🇨🇳Lanzhou, Gansu, China
Shandong provincial institute for endemic disease control
🇨🇳Jinan, Shandong, China
Tianjin Medical University
🇨🇳Tianjin, Tianjin, China