A single-centre, four-arm, randomised parallel trial of healthy eating, aerobic exercise and resistance training to reduce percent body fat in overweight or obese adolescents

Ottawa Hospital Research Institute (OHRI) (Canada) - formerly Ottawa Health Research Institute0 sites292 target enrollmentJune 22, 2007

Overview

Phase: 未知
Intervention: Not specified
Conditions: Sedentary post-pubertal overweight or obese youth aged 14 - 18 years
Sponsor: Ottawa Hospital Research Institute (OHRI) (Canada) - formerly Ottawa Health Research Institute
Enrollment: 292
Status: Completed
Last Updated: 7 years ago

Registry

who.int

Start Date

June 22, 2007

End Date

August 31, 2011

Last Updated

7 years ago

Study Type

Interventional

Sex

All

Sponsor

Ottawa Hospital Research Institute (OHRI) (Canada) - formerly Ottawa Health Research Institute

•1\. Male or female
•2\. Aged 14 to 18 years
•3\. Tanner stage IV or above
•4\. Body mass index (BMI) greater than or equal to 95th percentile for age, and gender (http://www.cdc.gov/growthcharts),
•greater than or equal to 85th percentile for age/gender with any of:
•4\.1\. Fasting glucose greater than or equal to 6\.0 fasting
•4\.2\. Two\-hour plasma glucose 7\.8 \- 11 mmol/L after 75 G oral glucose (impaired glucose tolerance)
•4\.3\. Fasting triglycerides greater than 1\.7 mmol/L
•4\.4\. Fasting plasma insulin greater than 105 pmol/L
•4\.5\. High density lipoprotein\-cholesterol (HDL\-C) less than 0\.9 mmol/L

•1\. Participation during the previous four months in a regular program of exercise or aerobic sports greater than or equal to two times per week for at least 20 minutes per session
•2\. Diabetes mellitus
•3\. Body weight over 159 kg, and/or BMI greater than 45 kg/m^2, exceeding capacity of dual energy X\-ray absorptiometry (DEXA) and computed tomography (CT) machines
•4\. Use of any performance\-enhancing medication
•5\. Use of any medication or herbal supplement that is likely to affect body composition, lipids or glucose metabolism
•6\. Significant weight change (increase of greater than or equal to 10%, or decrease greater than or equal to 5% of body weight during the two months before enrolment)
•7\. Uncontrolled hypertension: blood pressure (BP) greater than 150 mmHg systolic or greater than 95 mmHg diastolic BP in sitting position
•8\. Activity restrictions due to disease: unstable cardiac or pulmonary disease, significant arthritis
•9\. Other illness judged by the patient or study physician to make participation in this study inadvisable
•10\. Unwillingness/lack of availability to attend exercise and/or nutrition sessions at scheduled times and locations