Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Phase 4

• Conditions: Ischemia/Reperfusion Injury

• Registration Number: NCT00526695
• Lead Sponsor: University of Zurich

Brief Summary

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Detailed Description

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.

Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Study Timeline

• Study Start: 2005-01
• Study First Submitted: 2007-08-27
• Study First Submitted QC: 2007-09-06
• Study First Posted: 2007-09-10
• Status Verified: 2008-07
• Last Update Submitted: 2008-07-17
• Last Update Posted: 2008-07-18
• Primary Completion: 2008-12
• Study Completion: 2008-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
marker expression on blood cells	December 2008

Trial Locations

Locations (1)

University Hospital of Zurich; 🇨🇭 Zurich, Switzerland