Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery
Not Applicable
Completed
- Conditions
- Microvascular Breast Flap in Plastic Surgery
- Interventions
- Registration Number
- NCT01972230
- Lead Sponsor
- Regina Elena Cancer Institute
- Brief Summary
This study aimed to evaluate the possible protective effect of anesthetic technique balanced (BAL) compared to total intravenous anesthetic technique (TIVA-TCI) in ischemia reperfusion injury in microvascular flap in plastic surgery. The investigators will evaluate the viability of the flap using tissue oximetry monitoring and the level of biochemical markers in a circle at the end of the intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 128
Inclusion Criteria
- age > 18 yr
- ASA (American Society of Anesthesiology) I-II
Exclusion Criteria
- Known unusual reaction to anesthetic drugs
- Evaluation of anesthesia increased risk for malignant hyperthermia.
- History of vascular disease.
- History of bleeding diathesis.
- Tabagism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description TCI group Diprivan + Remifentanil TCI Propofol 3-4 mg / ml and remifentanyl 1-3 ng / ml according to protocol TCI Bilanced group Sevoflurane Sevofluorane adjusted to obtain an Et-Sevo of 1.8-2%, for all the time of the surgical procedure. Remifentanyl TCI adjusted according to protocol to maintain the range of 1-3 ng / ml.
- Primary Outcome Measures
Name Time Method tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously. 24 hours from the end of intervention
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Regina Elena Cancer Institute
🇮🇹Rome, RM, Italy