Neuroendocrine Mechanisms of Growth and Body Composition in Preterm and Term Infants
- Conditions
- Premature Birth
- Registration Number
- NCT00833222
- Lead Sponsor
- University of Utah
- Brief Summary
The purpose of this study is to test the feasibility of measuring body composition by air displacement plethysmography (ADP) in rapidly growing, medically stable late gestation \[32-35 weeks post-menstrual age (PMA)\] premature infants.
- Detailed Description
1. To assess the feasibility of measuring body fat deposition by ADP in medically stable late gestation (32-35 weeks), premature infants during a period of rapid postnatal growth.
2. To test the relationship between %BF by ADP to %BF by DXA, as well as characterize the relationship between these fat measures with bone measures by quantitative ultrasound and serum levels of insulin, IGF-1, IGF binding proteins, adiponectin and leptin.
3. To perform inter- and intra-rater testing of anthropometric, ultrasound, and ADP measurements.
4. Compare growth, body composition and bone strength between infants born preterm to infants born full term.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
- Infants born between 32 4/7 and 35 3/7 weeks gestation or 37 4/7 and 42 3/7 weeks gestation, by physical exam at birth
- Birth weight between the 5th and 95th percentile corrected for gestational age
- Chromosomal abnormalities
- Major congenital anomalies
- Major surgery
- Severe CNS injury
- Inborn errors of metabolism
- Assisted ventilation
- Inability to start enteral feeds by 96 hours of age
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Growth trajectory Weekly
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Utah
🇺🇸Salt Lake City, Utah, United States