Effect of Monitoring of Pulse Index Continuous Cardiac Output on Shock Patients in ICU
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 320
- Locations
- 1
- Primary Endpoint
- mortality at 28 days
Study Overview
Brief Summary
PiCCO has become a widely used haemodynamic monitoring device in the management of shock patients in ICU patients nowadays. But the effects on outcome of use of Picco, such as hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP in shock patients has not been determined. Patients will be randomly assigned to a Picco group or the control group, hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP will be observed. The conclusion will supply evidence for the clinical effectiveness of Picco in shock patients.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •critically ill patients with shock: Mean arterial pressure (MAP) < 65 mmHg (< 8,7 kPa) or systolic arterial pressure (SAP) < 90 mmHg (< 12 kPa) or the need for vasopressor (Norepinephrine <0.05µg/kg/min) to support the MAP ≥ 65 mmHg (≥ 8,7 kPa) or the SAP ≥ 90 mmHg ≥ 12 kPa), when one of these criteria has lasted for 4 hours or longer
Exclusion Criteria
- •Age < 18 years
- •Age > 85 years
- •Pregnancy (positive pregnancy test in women of child bearing age)
Outcomes
Primary Outcomes
mortality at 28 days
Time Frame: 28 days
mortality at 28 days after diagnosis of shock
Secondary Outcomes
- vasoactive agents-free days(28 days)
- intensive care unit-free days(28 days)
- mechanical ventilation-free days(28 days)
- the change of lactate at 1,3,7 days after the insertion of the Picco catheter(7 days)
- the change of B-Type Natruetic Peptide(BNP) at 1,3,7 days after the insertion of the Picco catheter(7 days)
- mortality at 90 days(90 days)
Investigators
Li danyang
Dr
Zhejiang University