跳至主要内容
临床试验/NCT06845657
NCT06845657招募中不适用

Effect of Hip Abductor Strengthening Exercises in Patients With Knee Osteoarthritis

Riphah International University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年3月3日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
40
试验地点
1
主要终点
Numeric Pain Rating Scale

研究概览

简要总结

The aim of this randomized controlled trial is to find the effect of hip abductor strengthening exercises on pain, range of motion, functional disability and balance in patient with knee osteoarthritis.

详细描述

Osteoarthritis (OA) is a chronic disease affecting the joint and its tissues, primarily leading to progressive damage to articular cartilage and, subsequently, to the subchondral bone and surrounding synovial structures. This chronic degenerative disease affects approximately one-third of adults, and its prevalence increasing with advancing age. The knee is one of the most common joints affected by the OA. Systematic reviews indicate a global prevalence of knee osteoarthritis (KOA) is 22.9% among individuals aged 40 and older, affecting an estimated 654.1 million people worldwide, with variations across countries and increasing with age.

Knee osteoarthritis (KOA) is a multi etiological, chronic disabling disease that affects the entire knee joint, which is the most common site of involvement in OA. KOA patients mostly suffer from progressive stiffness and knee pain. Gradually, they have some difficulties in performing daily activities, such as walking, squatting, and climbing and doing housework, as the disease progresses. Ultimately, pain and disability associated with the disease lead to a loss of functional independence and a profound reduction in quality-of- life. Impairments that are caused by KOA include knee pain, limited ROM of the knee, muscle weakness and knee instability.

The hip abductor muscles influence knee joint loading through their control of the pelvis in the frontal plane. Researchers have proposed that during the single-limb stance phase of gait, weakness of the stance-limb hip abductor muscles may lead to drop of the pelvis toward the contralateral limb, shifting the body's center of mass away from the stance limb toward the swing side. These adjustments, theoretically, could lead to higher knee adduction moments and greater medial knee joint loading.

Knee adduction moment is the moment that acts on the joint in the frontal plane. The knee adduction moment is generated by the combination of the ground reaction force, which passes medial to the centre of the knee joint during gait, and the perpendicular distance of this force from the centre of the joint. . This moment tends to adduct the tibiofemoral joint, causing an increase in medial compartment pressure, and people with knee OA have demonstrated larger than normal peak knee adduction moments in their gait patterns.

OA of the knee is characterized by changes in gait kinematics. High dynamic loads of the medial knee, as assessed by the external peak knee adduction moment, have been associated with tibiofemoral OA severity progression, and knee pain. The aging process impairs postural control more in a medial-lateral (ML) direction than in an anterior-posterior (AP) direction, which is linked with increased falling risk. Postural control stability in the ML direction, in orthostatic stance and during compensatory step, is dependent on hip abductor-adductor muscle torque .The hip abductor muscles are also needed to stabilize the lumbar-pelvic joint during gait and during balance recovery after external disturbance (postural responses of hip and step) This study aims to find the effect of hip abductor strengthening exercises on improving range of motion, functional activities, balance and minimizing pain in individuals affected by the knee OA.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
40 Years 至 60 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •• Age group 40-60
  • •Both genders male and female
  • •Have had knee pain for 3 months or more
  • •Report a minimum average overall pain severity of 4 on an 11-point numeric rating scale (NPRS) over the previous week
  • •grade II and III on X-ray (Kellgren and Lawrence classification);
  • •For participants with bilateral knee osteoarthritis, the more seriously affected side (as identified by the Kellgren-Lawrence grade of knee osteoarthritis and the pain intensity) was selected as the affected leg.
  • •willing to participate in intervention program

排除标准

  • •• history of surgery of lower limb
  • •Past knee fracture or malignancy
  • •individuals with known hip OA and/or previous trauma affecting one or both hips
  • •Intraarticular corticosteroid injection into the knee within previous 3 months.
  • •Pregnancy

研究组 & 干预措施

Hip Abductor Strengthening Exercises+ Conventional PT

Active Comparator

干预措施: Hip Abductor Strengthening Exercises (Other)

Conventional PT

Other

干预措施: Conventional Treatment (Other)

结局指标

主要结局

Numeric Pain Rating Scale

时间窗: 3 weeks

The Numeric Pain Rating Scale (NPRS) is a segmented numeric version of the visual analog scale which is used to assess pain. It scores ranges from 0-10, 0 means No pain and 10 means Severe pain. Patient will be asked to verbally report the pain score

Western Ontario and McMaster Universities Osteoarthritis Index

时间窗: 3 weeks

The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used, validated questionnaire assessing pain, stiffness, and physical function in patients with knee osteoarthritis. It consists of 24 items divided into three subscales: Pain (5 items), Stiffness (2 items), and Physical Function (17 items).

Timed Up and Go test

时间窗: 3 weeks

The Timed Up and Go (TUG) test measures the time taken by a participant to stand up from a standard chair, walk a distance of 3 meters, turn around, walk back to the chair, and sit down. It assesses dynamic balance and functional performance.

Single leg stance

时间窗: 3 weeks

The Single leg stance (SLS) Test is used to assess static postural and balance control. Participants are instructed to stand on one leg unassisted, with eyes open and hands on hips. The duration for which the position is maintained is recorded.

次要结局

  • Range of Motion of Knee Joint(3 weeks)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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