Contrasting the Brain Effects of Risperidone and Invega With Functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) Scanning
- Registration Number
- NCT00937261
- Lead Sponsor
- University of California, Irvine
- Brief Summary
The purpose of this study is to better understand brain function and psychiatric and neurological illness when taking Invega or Risperdal. The objective is to compare the brain effects of Invega to Risperdal in patients with Schizophrenia. This comparison will be evaluated with PET imaging, fMRI, and neurological ratings and assessments.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 96
Inclusion Criteria
- are currently taking Risperdal and have been on the medication for at least three weeks
- are diagnosed with schizophrenia
- are able to provide written informed consent
- can safely have an MRI
Exclusion Criteria
- are treatment resistant or intolerant to Risperdal
- have participated in another drug study in the past 28 days
- are pregnant or trying to become pregnant or are breastfeeding
- are colorblind
- have a history of alcohol, cannabis, or cocaine abuse within two weeks prior to the study
- have a current or past history of a major medical illness or have abnormal lab values which the study doctor feels is significant
- certain medications are also exclusionary including aripiprazole.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Risperdal Risperidone Risperdal 2-8mg per day Invega Paliperidone Invega 6-12mg per day
- Primary Outcome Measures
Name Time Method Comparison of BOLD signal activation and FDG metabolism of the DLPFC, superior temporal gyrus and amygdala, and their interaction between Invega and Risperdal approximately 6-10 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UC Irvine
🇺🇸Irvine, California, United States