Long Term Cardiac And Pulmonary Consequences Of TB (LONG TB)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 350
- 试验地点
- 3
研究概览
简要总结
Tuberculosis (TB) survivors often face health problems even after they are cured, such as lung and heart issues. This study aims to find out why some people develop these problems and others don’t, which will help doctors better predict and treat these conditions.
The study will follow 350 adults who have been newly diagnosed with TB and do not have any previous lung or heart diseases. These patients will be from various hospitals in India, South Africa, the Philippines, and Uganda. They will be monitored for one year after starting TB treatment. Participants will undergo various health tests to check their lung and heart functions. These tests will include breathing tests, walking tests, questionnaires about their respiratory health, and imaging tests like X-rays and scans. Blood samples will be taken to check for markers related to diabetes, inflammation, heart stress, and cholesterol levels. Sputum and blood samples will be stored for future research. The study aims to identify persistent lung and heart problems at the end of TB treatment and six months later. This research will help fill important gaps in our understanding of the long-term health effects of TB and provide valuable samples for future studies.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Adults more thab 18 years of age 2 Xpert Ultra PTB -MTB detected and subsequently confirmed by MTB culture 3 Ability and willingness to provide informed consent, including consent for blood and sputum collection and storage for future research.
排除标准
- •1 More than 7 days of TB treatment for current TB episode 2 Prior history of TB, regardless of treatment duration 3 Multi- or extensively-drug resistant pulmonary TB, or poly-resistant pulmonary TB 4 Extra-pulmonary TB without microbiologically confirmed pulmonary involvement 5 Prior physician diagnosis of any chronic lung disease or cardiovascular disease 6 Pregnant women or those who plan to get pregnant during the study period 7 Severe illness which, in the study clinician’s judgement, will interfere with the participants ability to complete all study visits.
研究者
Devasahayam J Christopher
Christian Medical College, Vellore