Clinical evaluation and mechanistic research of reinforcing the kidney and eliminating wet combined with platelet-rich plasma in the treatment of earlier period of knee oseoarthritis.
- Conditions
- Early osteoarthritis of the knee
- Registration Number
- ITMCTR2000003974
- Lead Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Meet the diagnostic criteria of western or Traditional Chinese medicine for knee osteoarthritis;
2. It meets the requirements for the indications of the diagnosis and treatment technology studied;
3. Compliance with Kellgren-lawrance X-ray classification level 0, Level I and Level II;
4. Sign the informed consent.
1. Patients who do not meet the diagnostic criteria and inclusion criteria for knee osteoarthritis.
2. Those who have received other relevant treatments, which may affect the effect indicators in this study.
3. Patients with life-threatening primary diseases such as cardiovascular and cerebrovascular diseases, liver and kidney diseases and mental diseases.
4. Exclude research diseases:
(1) rheumatic diseases: rheumatoid arthritis, ankylosing spondylitis, etc.;
(2) Infectious arthritis: joint tuberculosis, purulent arthritis, etc.;
(3) Reactive arthritis: allergic arthritis, thrombocytopenic purpura arthritis;
(4) Metabolic joint diseases: Kashin-beck disease, gout, etc.;
(5) Intra-articular tumor;
(6) Other specific joint diseases.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TCM clinical symptom score;Lequesne index score;Serum indexes (TGF-beta 1, BMP-2, Smad1);WOMAC Osteoarthritis Index score;
- Secondary Outcome Measures
Name Time Method