Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen

Completed

• Conditions: Severe Pneumonia Due to Other Pathogene; COVID-19 Severe Pneumonia
• Interventions: Biological: biological assays in particular on the lipid metabolism

• Registration Number: NCT04435223
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-07
• Primary Completion: 2020-05-07
• Study Completion: 2020-05-07
• Status Verified: 2020-06
• Study First Submitted: 2020-06-16
• Study First Submitted QC: 2020-06-16
• Study First Posted: 2020-06-17
• Last Update Submitted: 2020-06-19
• Last Update Posted: 2020-06-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (>=38 °C) Hypothermia (< 35°C) AND new radiologic pulmonary infiltrate
• At admission or within 48 hours following hospital admission
• With 2 qSOFA criteria: MAP =< 100 mmHg, Respiratory Rate >= 22, Glasgow score < 15 OR on mechanical ventilation OR under vasopressor
• Age > 18
• affiliated to social security

Exclusion Criteria

• Pregnancy
• immunodepression
• Pathology known to cause severe lymphopenia
• hospitalisation within 3 month before inclusion AND sepsis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Severe pneumonia due to other pathogene	biological assays in particular on the lipid metabolism	-
COVID-19 severe pneumonia	biological assays in particular on the lipid metabolism	-

Primary Outcome Measures

Name	Time	Method
Cholesterol concentration	Within 48 hours following hospital admission

Secondary Outcome Measures

Name	Time	Method
LDL cholesterol / HDL cholesterol/ Lipoprotein size and composition/ Non esterified Fatty acid/ Triglyceridemia/ CETP and PLTP activity/ apolipoprotein canceration/ lipid peroxidation/ Pro and anti inflammatory profile.	Within 48 hours following hospital admission	Ventilator free days (28 days)

Trial Locations

Locations (1)

Chu Dijon Bourgogne; 🇫🇷 Dijon, France