Carotid Atherosclerotic Disease Following Childhood Scalp Irradiation

Completed

• Conditions: Atherosclerosis

• Registration Number: NCT00590421
• Lead Sponsor: Assaf-Harofeh Medical Center

Brief Summary

Background: During the first half of the 20th century, scalp irradiation was a standard treatment for induction of epilation in children suffering from Tinea Capitis. These children are now more than 50 years old and the aim was to investigate the possible association between their childhood low dose irradiation exposure and development of carotid atherosclerotic disease in adulthood.

Methods: The study included 145 individuals treated by irradiation in their childhood, and 150 matched control subjects with no history of irradiation. B-mode ultrasound imaging and US Doppler were used to measure carotid and femoral stenosis and Intima-Media Thickness (IMT). Blood samples were taken for lipid profile and homocysteine evaluation.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-07
• Primary Completion: 2007-01
• Study Completion: 2007-11
• Status Verified: 2007-12
• Study First Submitted: 2007-12-31
• Study First Submitted QC: 2007-12-31
• Study First Posted: 2008-01-10
• Last Update Submitted: 2008-10-16
• Last Update Posted: 2008-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 295

Inclusion Criteria

• age 18 or older
• childhood scalp irradiation or mach controls
• writen informed consent

Exclusion Criteria

• inability to give written informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Assaf Harofeh Medical Center; 🇮🇱 Zerifin, Israel