The Effect of Different Etco2 Levels on the End-tidal Concentration of Sevoflurane in Patients Undergoing Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- end tidal concentration of sevoflurane
研究概览
简要总结
he assessment of adequate levels of anaesthesia traditionally relies not only on a patient's movement but also on the hemodynamic response (or both) to a surgical stimulus
详细描述
Currently a derivative of MAC namely, end tidal partial pressure (FET) displayed on the work station as concentration , maybe an alternative useful measure of the anaesthetic effect of an inhaled anaesthetic agent
. Many pharmacological factors have been associated with alterations in MAC and Mac derivatives such as nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and anesthetics.
However, few studies have focused on physiological factors, such as hypercarbia or hypocarbia. A correlation has been found between Paco2 and Etco2 in ventilated patients with healthy lungs. Some authors have suggested that Etco2 could be considered appropriate for estimating Paco2 even in critical patients. Knowledge of the effects of Paco2 on end tidal concentration of sevoflurane among patients undergoing laparoscopic cholecystectomy may help anaesthesiologists titrate sevoflurane carefully and precisely during different mechanical ventilation settings to avoid dose-dependent hypotension, impaired cardiac contractility, and hypothermia caused by excessive anaesthetic depth of sevoflurane.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of anaesthesiologist ASA physical status I, II
- •admitted for laparoscopic cholecystectomy
排除标准
- •Refusal of patients.
- •Patients with renal or liver dysfunction.
- •Patients with chronic pain other than cholelithiasis.
- •Cardiac disorders as uncontrolled hypertension, arrhythmia, Ischaemic heart disease, valvular heart disease and pulmonary hypertension.
- •Patient with haematological disorder as Sickle cell disease.
- •Chest patient as asthma, COPD.
- •Combined surgery .
- •History of allergy to any of the study drugs.
- •Patients with communication problems, cognitive dysfunction, or psychological disorders.
- •Patients who received analgesics or sedatives 24 h before a scheduled surgery.
- •Alcohol or drug abuse.
研究组 & 干预措施
low ETCO2
干预措施: low etco2 (Procedure)
normal ETCO2
干预措施: normal etco2 (Procedure)
high ETCO2
干预措施: high etco2 (Procedure)
结局指标
主要结局
end tidal concentration of sevoflurane
时间窗: Total time of operation
end tidal concentration of sevoflurane is measured by multiple gas analyser during operation
次要结局
未报告次要终点
研究者
tarek abdel hay mostafa
principle investigator
Tanta University