Nutritional Modulation of Learning and Decision Making and Their Underlying Neural Processes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes in cognition/behavior I
研究概览
简要总结
The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 40 years old
- •fluent in German
- •right-handed
- •able to safely undergo MRI scanning
- •BMI (Body-Mass-Index) between 18.5 and 29.9 kg/m2
排除标准
- •current medication that might interfere with the processes studied
- •any metabolic, gastrointestinal, cardiological, neurological, psychiatric or any recurring or chronic diagnoses
- •alcohol consumption > 10 g/d for women and > 20 g/d for men
- •shifted circadian rhythm (e.g. jetlag, shift work)
- •vegan or vegetarian diet
- •food intolerances
- •females: hormonal contraception, pregnancy, lactation
结局指标
主要结局
Changes in cognition/behavior I
时间窗: 3-4.5 hours (post-meal)
Changes in learning behavior assessed via computer-based learning task ("predictive inference task") which tracks choices and response times (allows for calculation of learning-related scores: change in prediction choice following feedback)
Changes in cognition/behavior II
时间窗: 3-4.5 hours (post-meal)
Changes in decision-making behavior assessed via computer-based decision task ("gamble task") which tracks choices (calculation of gamble acceptance frequencies) and response times.
Changes in brain activity
时间窗: 3-4.5 hours (post-meal)
Changes in brain activity measured via functional magnetic resonance imaging;
次要结局
- Changes in metabolic parameters I(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters II(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters III(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters IV(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in subjective affective state(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in experienced hunger(rom baseline (prior meal) to approx. 4.5 hours after meal at several time points)
研究者
Stefan Schulreich
Ass.-Prof. Dr.
University of Vienna