Nutritional Modulation of Cognition and Brain Activity

Not Applicable

Recruiting

• Conditions: Cognitive Change; Nutrition, Healthy; Brain Activity

• Registration Number: NCT06386237
• Lead Sponsor: University of Vienna

Brief Summary

The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-04
• Study First Submitted: 2024-04-07
• Study Start: 2024-04-08
• Study First Submitted QC: 2024-04-22
• Last Update Submitted: 2024-04-22
• Study First Posted: 2024-04-26
• Last Update Posted: 2024-04-26
• Primary Completion: 2025-02-28
• Study Completion: 2025-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 18 to 40 years old
• fluent in German
• right-handed
• able to safely undergo MRI scanning
• BMI (Body-Mass-Index) between 18.5 and 29.9 kg/m2

Exclusion Criteria

• current medication that might interfere with the processes studied
• any metabolic, gastrointestinal, cardiological, neurological, psychiatric or any recurring or chronic diagnoses
• drug use
• alcohol consumption > 10 g/d for women and > 20 g/d for men
• smoking
• shifted circadian rhythm (e.g. jetlag, shift work)
• vegan or vegetarian diet
• food intolerances
• females: hormonal contraception, pregnancy, lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes in cognition/behavior I	3-4.5 hours (post-meal)	Changes in learning behavior assessed via computer-based learning task ("predictive inference task") which tracks choices and response times (allows for calculation of learning-related scores: change in prediction choice following feedback)
Changes in cognition/behavior II	3-4.5 hours (post-meal)	Changes in decision-making behavior assessed via computer-based decision task ("gamble task") which tracks choices (calculation of gamble acceptance frequencies) and response times.
Changes in brain activity	3-4.5 hours (post-meal)	Changes in brain activity measured via functional magnetic resonance imaging;

Secondary Outcome Measures

Name	Time	Method
Changes in metabolic parameters I	from baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in the concentrations of amino acids (assessed via blood samples and chemical analysis)
Changes in metabolic parameters II	from baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in the concentrations of glucose (assessed via blood samples and chemical analysis)
Changes in metabolic parameters III	from baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in the concentrations of insulin (assessed via blood samples and chemical analysis)
Changes in metabolic parameters IV	from baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in the concentration of cortisol (assessed via saliva samples and chemical analysis)
Changes in subjective affective state	from baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in reported affect ("Multidimensionaler Befindlichkeitsfragebogen" - multidimensional mood scale; Steyer et al., 1997)
Changes in experienced hunger	rom baseline (prior meal) to approx. 4.5 hours after meal at several time points	Changes in subjective reported hunger (assessed via single-item Likert-Scale)

Trial Locations

Locations (1)

University of Vienna; 🇦🇹 Vienna, Austria