Nutritional Modulation of Learning and Decision Making and Their Underlying Neural Processes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nutrition, Healthy
- Sponsor
- University of Vienna
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Changes in cognition/behavior I
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.
Investigators
Stefan Schulreich
Ass.-Prof. Dr.
University of Vienna
Eligibility Criteria
Inclusion Criteria
- •18 to 40 years old
- •fluent in German
- •right-handed
- •able to safely undergo MRI scanning
- •BMI (Body-Mass-Index) between 18.5 and 29.9 kg/m2
Exclusion Criteria
- •current medication that might interfere with the processes studied
- •any metabolic, gastrointestinal, cardiological, neurological, psychiatric or any recurring or chronic diagnoses
- •alcohol consumption \> 10 g/d for women and \> 20 g/d for men
- •shifted circadian rhythm (e.g. jetlag, shift work)
- •vegan or vegetarian diet
- •food intolerances
- •females: hormonal contraception, pregnancy, lactation
Outcomes
Primary Outcomes
Changes in cognition/behavior I
Time Frame: 3-4.5 hours (post-meal)
Changes in learning behavior assessed via computer-based learning task ("predictive inference task") which tracks choices and response times (allows for calculation of learning-related scores: change in prediction choice following feedback)
Changes in cognition/behavior II
Time Frame: 3-4.5 hours (post-meal)
Changes in decision-making behavior assessed via computer-based decision task ("gamble task") which tracks choices (calculation of gamble acceptance frequencies) and response times.
Changes in brain activity
Time Frame: 3-4.5 hours (post-meal)
Changes in brain activity measured via functional magnetic resonance imaging;
Secondary Outcomes
- Changes in metabolic parameters I(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters II(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters III(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in metabolic parameters IV(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in subjective affective state(from baseline (prior meal) to approx. 4.5 hours after meal at several time points)
- Changes in experienced hunger(rom baseline (prior meal) to approx. 4.5 hours after meal at several time points)