Platelet Inhibition and Bleeding in Patients Undergoing Emergent Cardiac Surgery

Completed

• Conditions: Bleeding

• Registration Number: NCT01468597
• Lead Sponsor: Medical University of Graz

Brief Summary

The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing emergent cardiac surgery during dual antiplatelet therapy.

Detailed Description

Blood for measuring platelet function is drawn before induction of anesthesia

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-10-04
• Study First Submitted QC: 2011-11-07
• Study First Posted: 2011-11-09
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Results First Submitted: 2020-03-09
• Status Verified: 2020-06
• Results First Submitted QC: 2020-06-17
• Last Update Submitted: 2020-06-17
• Results First Posted: 2020-06-18
• Last Update Posted: 2020-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 167

Inclusion Criteria

• First time on-pump CABG with or without valve replacement

Exclusion Criteria

• Redo surgery,
• Renal insufficiency needing dialysis,
• Concomitant medication with warfarin,
• Preoperative fibrinogen < 150 mg%

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calculated Blood Loss	until postoperative day 5

Secondary Outcome Measures

Name	Time	Method
BARC Bleeding	until postoperative day 2	Intracranial bleed within 48 hours, Reoperation after closure of sternotomy for the purpose of controlling bleeding, Transfusion of equal to or more than 5 Units of packed red blood cells within a 48-hour period, Chest tube output of equal to or more than 2 L within a 24-h period.

Trial Locations

Locations (1)

Department of Anesthesiology and Intensive Care Medicine, Department of Surgery, Medical University of Graz; 🇦🇹 Graz, Austria