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Clinical Trials/NCT04643171
NCT04643171
Unknown
Not Applicable

Markers of Oxidative Stress in Response to Electroacupuncture Against Aerobic Physical Activity in Diabetic Patients

Cairo University1 site in 1 country60 target enrollmentNovember 19, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Diabetes Mellitus, Type 2
Sponsor
Cairo University
Enrollment
60
Locations
1
Primary Endpoint
superoxide dismutase
Last Updated
5 years ago

Overview

Brief Summary

OS is an important pathogenetic mechanism for the development of T2DM and its complications.

Oxidative stress is an imbalance of the generation of free radicals or known as reactive oxygen species (ROS) and reactive nitrogen species [RNS]) and their neutralization by the antioxidant mechanisms.

Increased levels of ROS and RNS lead to damage of lipids, proteins, and DNA, ultimately causing the destruction of the islet cells of pancreas through apoptosis . Elliptical trainer device is a relatively new modality of exercise and is advertised to be superior to a treadmill because of the low joint impact and the more reasonable costs of an elliptical trainer compared to a treadmill . Additional quantative research is needed to further evaluate the effectiveness of elliptical trainers and the physiological and perceptual responses to the machine Electroacupuncture (EA) is a treatment form of traditional acupuncture in which small electrical currents are passed through needles inserted into the subject's skin using EA stimulator. It seems to have more acceptable results and effects on many important clinical applications and medical research sets .

Detailed Description

60 diabetic patients will be randomly divided to electroacupucture group (30 patients) and high intensity elliptical training (30 patients). the treatment will be done for 5 sessions per week for 12 weeks

Registry
clinicaltrials.gov
Start Date
November 19, 2020
End Date
March 1, 2021
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Ali Mohamed Ali ismail

lecturer of Physical Therapy for Cardiovascular / Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University

Cairo University

Eligibility Criteria

Inclusion Criteria

  • type 2 diabetic elderly
  • Body mass index less than 30 kg/m
  • Fasting blood more than 126 mg/dl

Exclusion Criteria

  • cardiac patients
  • renal patients
  • respiratory patients
  • liver patients
  • patients who received any complementary therapies within 3 past months

Outcomes

Primary Outcomes

superoxide dismutase

Time Frame: It will be measured after 12 weeks

marker of anti-oxidative stress

Secondary Outcomes

  • nitric oxide(It will be measured after 12 weeks)
  • lipid hydroperoxidase(It will be measured after 12-week training)

Study Sites (1)

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