Longevity Families of the Netherlands

Recruiting

• Conditions: Aging; Longevity; Familial Longevity; Extreme Longevity

• Registration Number: NCT06374069
• Lead Sponsor: Leiden University Medical Center

Brief Summary

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-11
• Study First Submitted: 2024-03-20
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-15
• Last Update Submitted: 2024-04-15
• Study First Posted: 2024-04-18
• Last Update Posted: 2024-04-18
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
• Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identifying the genetic variants of Familial Longevity	through study completion, an average of 2 years	To identify gene variants associated with healthy aging and protection from (multi)morbidity

Secondary Outcome Measures

Name	Time	Method
Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component	through study completion, an average of 2 years	To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component

Trial Locations

Locations (1)

Leiden University Medical Center; 🇳🇱 Leiden, South Holland, Netherlands