PACTR202102566734864已完成1 期
Drug-drug interaction in the co-administration of the antiretroviral drugs and the antischistomicide praziquantel
AiBST0 个研究点目标入组 32 人开始时间: 2020年5月4日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19 Year(s) 至 44 Year(s)（—）
- 性别
- Male
入选标准
- •Black Zimbabwean
- •Age between 18 and 40 years
- •BMI between 18 and 30
- •HIV, Hepatitis B and C negative
- •Able to give consent
- •Non-smoking
- •Lab screening and ECG within the limits stipulated in the protocol
- •Healthy as determined by medical examination
排除标准
- •HIV positive
- •any current or past history of psychiatric disorder
- •subjects receiving any prescription or over the counter product
- •use of any recreational drug
- •subjects who have eaten grapefruit or drunk grapefruit juice during the last 15 days before administration of study drug
- •subjects who had xanthine containing beverages (coffee, tea, chocolates, etc) 48 hours prior to study drug administration
- •history of hepatic, renal, GI, heart, lung, neurological, endocrine, chronic infections or disease
- •subjects suffering from any acute disease at screening or check in
- •Alanine S. Transaminase (AST)/ Alanine L. Transaminase (ALT) >3 times upper limit of normal (ULN)
- •Bilirubin >2.5 times ILN
- •Amylase > 2 times ULN
- •Absolute Neutrophil Count <1000/ml
- •Hgb < 9.0g/dl
- •Platelets > 50 000 cells/mm3
- •serum creatinine >2.5 mg/dl
研究者
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