Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)
- Conditions
- Peripheral Arterial Disease
- Registration Number
- NCT01377649
- Lead Sponsor
- Oregon Health and Science University
- Brief Summary
Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells. In this study, the investigators hypothesize that contrast ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by medications that mimic exercise (vasodilator stress) can provide information on the location and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The investigators will also determine whether symptom improvement after revascularization (procedures to open up or bypass the blockages) is directly related to the improvement in blood flow.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
- Known or suspected PAD
- Lower extremity angiography or MRA planned or performed within 6 months
- Age <19 y.o.
- Pregnant or lactating females
- Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson
- Severe reactive airways disease
- Evidence right-to-left shunt (identified on screening echo)
- NYHA Class III or IV heart failure.
- Planned amputation
- Unstable coronary artery disease or severe aortic stenosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantitation of Perfusion Immediate Correlation of skeletal muscle perfusion with symptom status
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oregon Health & Science University
🇺🇸Portland, Oregon, United States