NCT01039831Unknown不适用
The Role of White Matter Pathology in the Development of the Postural Instability and Gait Disturbance (PIGD) Type of Parkinson's Disease (PD)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
研究概览
简要总结
The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown. We hypothesize that sub-clinical WM pathology may be a major contributing factor to PIGD-PD. We will compare two groups of patients with Parkinson's disease (PD): those with PIGD and patients with dominant tremor (n=120)to assess the role of brain WM changes.
详细描述
To compare brain WM burden using MRI in PD patients with and without PIGD. Diffusion tensor imaging (DTI) analysis techniques will be applied.We will quantify PIGD-related symptoms including cognitive function, balance and gait and their associations with MRI findings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of idiopathic PD, as defined by the UK Brain Bank criteria
- •Age between 50 and 80 years
- •Hoehn and Yahr stage II-III
- •On anti-parkinsonian medications
- •Mini-Mental State Exam score ≥ 25
排除标准
- •Brain surgery in the past including implanted Deep Brain Stimulation
- •Clinically significant co-morbidities likely to affect gait e.g., acute illness, significant rheumatic, orthopedic disease, dementia, or major depression
- •Unable to walk independently
- •Inability to comply with the protocol
研究者
研究点 (1)
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