NCT02962076终止早期 1 期
Cardiac Positron Emission Tomography for Detection of Cardiac Sympathetic Dysinnervation to Guide Ablation of Ventricular Tachycardia
适应症
干预措施
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Correlation Between PET Data and Electroanatomic Data
研究概览
简要总结
Imaging is to be performed prior to procedure using positron emission tomography/ computed tomography (PET/CT), after a special dye is injected. The scans are going to be merged with other cardiac scans when doing the ablation procedure to correlate anatomy with physiology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical indication for ventricular tachycardia (VT) ablation (at least one clinical episode of sustained VT) despite antiarrhythmic drug therapy, or if the patient does not wish to be on one
- •Ischemic or nonischemic cardiomyopathy
- •Sustained monomorphic VT
排除标准
- •Right ventricular VT
- •Polymorphic VT or ventricular fibrillation (VF) being the sole detected clinical arrhythmia
- •Patient is unable to sign informed consent
- •Recent myocardial infarction less than 30 days
- •Recent ablation for ventricular tachycardia less than 30 days
- •Patient is unwilling or unable to cooperate with the study
- •Prosthetic mitral or aortic valve
- •General contraindications to VT ablation, e.g., major contraindication to anticoagulation therapy, known presence of left ventricular thrombus, reversible causes of VT or VF
- •General contraindications to PET imaging, e.g., pregnancy or lactation
- •General contraindication to magnetic resonance imaging or to the administration of gadolinium.
- •Contraindication to the placement of hemodynamic support devices, i.e. the presence of mechanical valves or lack of adequate vascular access
研究组 & 干预措施
Single Arm - PET/CT Imaging With [C-11] MHED
Experimental
Single Arm - positron emission tomography/computed tomography imaging with [C-11] meta-Hydroxyephedrine tracer
干预措施: [C-11] Meta-hydroxyephedrine radioactive tracer (MHED) (Drug)
结局指标
主要结局
Correlation Between PET Data and Electroanatomic Data
时间窗: 1 week
次要结局
未报告次要终点
研究者
研究点 (1)
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