Cardiac Positron Emission Tomography for Detection of Cardiac Sympathetic Dysinnervation to Guide Ablation of Ventricular Tachycardia

Khaled Awad, MD1 site in 1 country11 target enrollmentSeptember 21, 2020

ConditionsVentricular Tachycardia

Interventions[C-11] Meta-hydroxyephedrine radioactive tracer (MHED)

Overview

Phase: Early Phase 1
Intervention: [C-11] Meta-hydroxyephedrine radioactive tracer (MHED)
Conditions: Ventricular Tachycardia
Sponsor: Khaled Awad, MD
Enrollment: 11
Locations: 1
Primary Endpoint: Correlation Between PET Data and Electroanatomic Data
Status: Terminated
Last Updated: last year

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Imaging is to be performed prior to procedure using positron emission tomography/ computed tomography (PET/CT), after a special dye is injected. The scans are going to be merged with other cardiac scans when doing the ablation procedure to correlate anatomy with physiology.

Registry

clinicaltrials.gov

Start Date

September 21, 2020

End Date

October 31, 2024

Last Updated

last year

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Khaled Awad, MD

Responsible Party

Sponsor Investigator

Principal Investigator

Khaled Awad, MD

Mercy Research

Eligibility Criteria

Inclusion Criteria

•Clinical indication for ventricular tachycardia (VT) ablation (at least one clinical episode of sustained VT) despite antiarrhythmic drug therapy, or if the patient does not wish to be on one
•Ischemic or nonischemic cardiomyopathy
•Sustained monomorphic VT

Exclusion Criteria

•Right ventricular VT
•Polymorphic VT or ventricular fibrillation (VF) being the sole detected clinical arrhythmia
•Patient is unable to sign informed consent
•Recent myocardial infarction less than 30 days
•Recent ablation for ventricular tachycardia less than 30 days
•Patient is unwilling or unable to cooperate with the study
•Prosthetic mitral or aortic valve
•General contraindications to VT ablation, e.g., major contraindication to anticoagulation therapy, known presence of left ventricular thrombus, reversible causes of VT or VF
•General contraindications to PET imaging, e.g., pregnancy or lactation
•General contraindication to magnetic resonance imaging or to the administration of gadolinium.