The Effect of Delayed Cord Clamping and Milking on the Amount of Endogenous Stem Cells In Preterm Infants
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Concentration of Stem cells
研究概览
简要总结
Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.
In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- — 至 30 Minutes（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Infants born under 32 weeks of gestation
- •Accepted to participate with informed consent
- •History of healthy pregnancy
- •Infants born and will be followed up at the study hospital
排除标准
- •Congenital abnormalities
- •Chromosomal abnormalities
- •Declined to participate
结局指标
主要结局
Concentration of Stem cells
时间窗: 6 months
Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping.
次要结局
- Number of Participants with Neonatal Morbidities(6 months)
研究者
Merih Cetinkaya
Neonatologist
Kanuni Sultan Suleyman Training and Research Hospital