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The Effect of Delayed Cord Clamping and Milking on the Amount of Stem Cells In Preterm

Not Applicable
Conditions
Umbilical Cord; Clamping Time
Registration Number
NCT04057027
Lead Sponsor
Kanuni Sultan Suleyman Training and Research Hospital
Brief Summary

Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.

In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
90
Inclusion Criteria
  • Infants born under 32 weeks of gestation
  • Accepted to participate with informed consent
  • History of healthy pregnancy
  • Infants born and will be followed up at the study hospital
Exclusion Criteria
  • Congenital abnormalities
  • Chromosomal abnormalities
  • Declined to participate

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Concentration of Stem cells6 months

Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping.

Secondary Outcome Measures
NameTimeMethod
Number of Participants with Neonatal Morbidities6 months

Recording newborn morbidities such as intraventricular hemorrhage , necrotizing enterocolitis, bronchopulmonary dysplasia , retinopathy of prematurity which are detected in the study population.

Trial Locations

Locations (1)

Istanbul Kanuni Sultan Suleyman Training and Research Hospital

🇹🇷

Istanbul, Turkey

Istanbul Kanuni Sultan Suleyman Training and Research Hospital
🇹🇷Istanbul, Turkey
Seda Yilmaz Semerci
Contact
05337180683
sedayilmazsemerci@gmail.com

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