EVALUATE THE EFFECT OF USE OF TRIIDOTHYRONINE T3 HORMONE TABLET IN CHILDREN UNDERGOING HEART SURGERIES.
Phase 4
- Conditions
- Health Condition 1: I272- Other secondary pulmonary hypertension
- Registration Number
- CTRI/2021/03/032122
- Lead Sponsor
- Department of Cardiac Anaesthesia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
all children less than 1 year of age undergoing complex cardiac surgeries like arterial switch operation, vsd with PAH, TAPVC repair under CPB
Exclusion Criteria
Children who have history of radiation therapy, abnormal baseline thyroid function,
thyroid diseases and other endocrine diseases, preoperative thyroid hormone therapy,
use of drugs affecting thyroid function,
and preoperative use of inotropic drugs for circulatory support,
serum level of creatinine >2.0mg/dL downs syndrome mortality during study will be excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the effect of Triidothyronine therapy on ionotropic requirement (mean ionotropic scores on 3rd postoperative day) in post complex congenital cardiac surgery under cardiopulmonary bypass <br/ ><br>Timepoint: 3rd postop day <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1. To compare Thyroid hormone profile. <br/ ><br> 2.To compare left ventricular function by assessing Left ventricular outflow tract velocity time integral(LVOT VTi), Ejection by echo <br/ ><br>3.To assess the effect of T3 on ionotropic requirement in post complex congenital cardiac surgeries in infants. <br/ ><br>4.To compare pulmonary function by assessing PaO2/FiO2 Ratio. <br/ ><br>5.To compare 24 hours fluid balance. <br/ ><br>6.To compare ventilation time, ICU Length of stay. <br/ ><br>7. Arrhythmias <br/ ><br>8. Sepsisbetween the two groups <br/ ><br>Timepoint: pod 0,1,2,4,5