Effects of sub chronic oral tryptophan administrations on stress-induced mood and eating behaviour in healthy female volunteers differing in the 5-HTTLPR genotype

Completed

Conditions: emotional eating
stress-induced eating
10003018

Registration Number: NL-OMON37605

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Age between 18 and 30 years
Body Mass Index (BMI) between 20 and 25 kg/m2
Beck Depression Inventory score (BDI; Beck et al. 1961) below 11
Subjects willing and able to give written informed consent and to understand, to participate and to comply with the research project requirements.

Exclusion Criteria

Chronic and/or current illness
Personal or family history of psychiatric illness
Prescription medication use
Experience with panic attack/hyperventilation attack
Excessive use of alcohol (>1 units per day, 1 unit: 300ml beer, 1 glass of wine or 1 measure of spirit), coffee and/or drugs
Smoking
Any use of alcohol or drugs during the experiment, starting 2 days before the experimental session until the end of the experiment
Pregnancy and breast feeding
(also see section 4.3 of research protocol)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>the main study parameters are changes in mood, state-anxiety, eating behaviour<br /><br>(anticipated preference, appetite, and actual intake and macronutrient<br /><br>selection) and salivary cortisol, both before and after TRP or PLC treatment<br /><br>and before and after stress-induction. Blood samples will be taken twice on the<br /><br>first, and twice on the final day of treatment, to measure dietary (TRP)<br /><br>induced changes in plasma amino acids (TRP/LNAA ratio).</p><br>

Secondary Outcome Measures