Tryptophan depletion in patients with selective serotonin reuptake inhibitor-remitted generalised anxiety disorder or obsessive compulsive disorder.
Not Applicable
Completed
- Conditions
- Obsessive compulsive disorder (OCD)Mental Health - Anxiety
- Registration Number
- ACTRN12609000170224
- Lead Sponsor
- niversity of Western Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
Generalised anxiety disorder or obsessive compulsive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; good response to a selective serotonin reuptake inhibitors (clinical dose ajusted)
Exclusion Criteria
Comorbid bipolar disorder, psychotic disorder, substance misuse disorder, major madical condition, the use of other psychiatric medication, pregnant, breastfeeding.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Generalised anxiety disorder specific symptoms or obsessive compulsive disorder specific symptoms, measured using the Visual Analogue Scale items:<br>Generalised anxiety disorder (GAD) - worried and anxious<br>Obsessive compulsive disorder (OCD) - interfering and anxious[pre and peak response following disorder specific provocation (5 hours post amino acid mixture ingestion).]
- Secondary Outcome Measures
Name Time Method Generalised anxiety disorder specific symptoms or obsessive compulsive disorder specific symptoms. For GAD - Spielberger State Anxiety Inventory and for<br>OCD - Yale Brown Obsessive Compulsive Scale (YBOCS)[pre and peak response following disorder specific provocation (5 hours post amino acid mixture ingestion):]