The effects of Acute Tryptophan Depletion in individuals with a history of depression with and without anger attacks
Completed
- Conditions
- depressionsad mood10027946
- Registration Number
- NL-OMON32412
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- Age between 18 and 65 years; - Meeting DSM-IV criteria for past depression as a primary diagnosis; - Having at least 2 episodes of past depression OR having at least one first-degree relative with recurrent MDD; - A Hamilton depression rating scale (HDRS)-score lower than 10 OF MADRS < 12; - Depression in remission for at least 3 months; - Free of antidepressant medication for at least 1 month or for more than 5 elimination half-lives of the drug, whichever is more.
Exclusion Criteria
- Major physical illness; - Substance abuse within the last 3 months; - Lactation
- Pregnancy; - History or current Psychotic Disorder or Bipolar Disorder; - Using medication likely to affect CNS function, incl. benzodiazepines
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is change in symptoms following ATD compared to<br /><br>placebo (MADRS and Spielberger State anger as primary measures); </p><br>
- Secondary Outcome Measures
Name Time Method <p> serotonin transporter and polymorphisms of the 5-Ht1A C(-1019)G gene and the<br /><br>mineralocorticoid and glucocorticoid receptor-genes</p><br>