Association Between the Triglyceride-glucose Index and the Ratio of Triglyceride to High-density Lipoprotein Cholesterol With Fetal Macrosomia in Low-risk Nulliparous Pregnant Women
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 302
- 试验地点
- 1
- 主要终点
- The triglyceride to high density lipoprotein cholesterol ratio
研究概览
简要总结
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.
The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality.
While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.
详细描述
In this study, the investigators aimed to investigate whether the ratio of triglycerides to high-density lipoprotein cholesterol and the triglyceride glucose index are associated with fetal macrosomia in low-risk nulliparous pregnant women.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG).
- •Low-risk nulliparous singleton pregnant women.
- •Age between 18 and 40 years old
排除标准
- •Post-term pregnancies
- •Hospitalized for preterm labor or preterm premature rupture of membranes.
- •Gestational diabetes mellitus, diabetes mellitus type I - type II.
- •Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia.
- •Multiparous pregnant women
- •Multiple pregnancies
- •Pregnant women with chronic diseases.
- •Pregnant women with impaired liver function;
- •Pregnant women with body mass index <25 and >40 kg/m2.
结局指标
主要结局
The triglyceride to high density lipoprotein cholesterol ratio
时间窗: between 28 and 40 weeks of pregnancy
The triglyceride to high density lipoprotein cholesterol ratio was calculated from the blood samples taken from pregnant women in the third trimester.
The TyG index
时间窗: between 28 and 40 weeks of pregnancy
The triglyceride-glucose index was determined using the formula Ln \[fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2\], with blood samples taken from pregnant women in the third trimester.
次要结局
- HOMA-IR(between 28 and 40 weeks of pregnancy)
研究者
Fahri Burcin Firatligil
Specialist doctor in obstetrics and gynecology and Fellow student in Perinatology
Ankara Etlik City Hospital