Functional anatomy and impact of cognitive training on chunking within working memory in early Alzheimer's disease

Not Applicable

Completed

• Conditions: Early Alzheimer's disease; Nervous System Diseases; Alzheimer's disease

• Registration Number: ISRCTN43007027
• Lead Sponsor: Institute of Psychiatry (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02-07
• Last Update Posted: 28 November 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Aged greater than 60 years, either sex
2. Diagnosis of probable Alzheimer's disease according to National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria
3. Mini-Mental State Examination (MMSE) score greater than 23/30
4. All subjects will be required to provide informed consent to participate in the study

Exclusion Criteria

1. Co-existent neurological or psychiatric disease
2. Substance misuse
3. Significant auditory or visual impairment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Scores on verbal working memory task<br>2. Cerebral blood flow in the prefrontal and parietal cortices as measured using fMRI<br>Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention).

Secondary Outcome Measures

Name	Time	Method
Scores on:<br>1. Spatial working memory task<br>2. Sustained attention, reasoning and episodic memory tasks<br>3. Artificial grammar task<br>4. Instrumental activities of daily living (ADL) task<br>Measured at baseline and after 8 weeks (following the 6 week cognitive training intervention).