Comparison of efficacy and safety of intravenous Alteplase (rt-PA) versus Aspirin therapy to improve outcome in patients with acute ischemic stroke

Faculty of medicine0 个研究点目标入组 80 人开始时间: 2019年4月14日最近更新: 2023年5月29日

适应症

试验速览

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•1. Evidence of intra-cranial hemorrhage on non-contrast CT (computerized tomography).
•2. Clinical suspicion of sub-arachnoid hemorrhage even with normal CT.
•3. CT shows multi-lobar infarction (hypo-density greater than 1/3 cerebral hemisphere).
•4. History of intra-cranial hemorrhage.
•5. Uncontrolled hypertension: at time treatment systolic blood pressure remains>185 mm hg or diastolic blood pressure remains>110 despite repeated measurements.
•6. Known arteriovenous malformation, neoplasm, or aneurysm.
•7.Witnessed seizure at stroke onset.
•8.Acute bleeding tendencies as low platelet count < 10000/mm3, heparin received prior 48 hours with elevated PTT, or current use of anticoagulant (Coumadin /warfarin) with elevated INR.
•9.Intra-cranial or spinal surgery, or head trauma within prior 3 months.
•10. Arterial puncture at non compressible site within last 7 days.
•11. Woman of child bearing age who has a positive pregnancy test.
•12. NIH stroke scale>22 (sever deficit) or <4 and no dysphasia (mild deficit) or rapidly improving symptoms.
•13. 14 days post-operative or post trauma.
•14. Recent GI or urinary tract hemorrhage (prior 21 days).
•15. Recent acute myocardial infarction (prior 3 months).
•16. Post myocardial infarction pericarditis.
•17. Glucose level < 50 which is resistant for correction by glucose infusion.

发起方

Faculty of medicine