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临床试验/NCT06372886
NCT06372886已完成不适用

Clinical Outcomes of Preservation Versus Resection of Portal/Superior Mesenteric Vein During Pancreaticoduodenectomy in Pancreatic Cancer Patients Who Respond to Neoadjuvant Treatment

Seoul National University Hospital0 个研究点目标入组 264 人开始时间: 2012年1月1日最近更新:
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适应症

试验速览

阶段
不适用
状态
已完成
入组人数
264
主要终点
5-year overall survival
研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

  1. There is a lack of evidence on the need to perform portal/superior mesenteric vein (PV/SMV) resection routinely in pancreatic ductal adenocarcinoma (PDAC) patients with venous involvement who responded to neoadjuvant treatment (NAT).
  2. There is no significant differences in R0 rate, 5-year overall survival and recurrence-free survival between the PV/SMV preservation (PVP) group and PV/SMV resection (PVR) group.
  3. PVP group showed significantly better 5-year PV/SMV stenosis free survival than the PVR group.
  4. We propose that if dissection is possible and there is a high likelihood of achieving R0 resection after NAT, routine PVR may be unnecessary in PDAC patients with venous involvement.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
— 至 79 Years（Child, Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •Pancreatic head cancer patients who underwent surgery after neoadjuvant treatment between January 2012 and December 2022 at Seoul National University Hospital

排除标准

  • •Metastatic unresectable and locally advanced pancreatic cancer
  • •Resectable pancreatic cancer without portal/superior mesenteric vein invasion
  • •Cancer aggravation after neoadjuvant treatment
  • •Portal/superior mesenteric vein encasing and narrowing after neoadjuvant treatment
  • •Patients who underwent palliative surgery
  • •Non-pancreatic ductal adenocarcinoma patients
  • •Patients who death within 30 days of surgery
  • •Loss of follow-up patients
  • •Patients who underwent resection for suspected main artery and adjacent organ invasion

结局指标

主要结局

5-year overall survival

时间窗: assessed up to 60months

from diagnosis to any cause of death

5-year portal/superior mesenteric vein stenosis free survival

时间窗: assessed up to 60months

from surgery to stenosis

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jin-Young Jang

Professor

Seoul National University Hospital

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