A follow-up of infants born following intrauterine growth restriction: Is there a relation between neonatal cerebral tissue oxygenation and developmental outcome at 4 years?

Completed

Conditions: ontwikkelingsstornissen
ontwikkeling
10028920
fetal growth retardation
intrauterine growth restriction (IUGR)

Registration Number: NL-OMON43109

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- Survivor of the IUGR cohort of a previous study performed in the UMCG, METc number 2012-055
- Near-infrared spectroscopy (NIRS) data available from the first week after birth
- Written informed consent

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Chromosomal disorders
- Congenital infections
- Significantly impaired hearing or vision
- Inability to understand/speak Dutch

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The total IQ based on the Wechsler Preschool and Primary Score of Intelligence<br /><br>(WPPSI) with subdivision into the verbal IQ and the performance IQ. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>a) The emotional and social behaviour as assessed with the Children Behavior<br /><br>Checklist (CBCL), the executive functioning assessed with the Behavior Rating<br /><br>Inventory of Executive Function-Preschool Version (BRIEF-P), and the<br /><br>developmental progress as assessed by the Ages and Stages Questionnaire (ASQ).<br /><br><br /><br>b) The DNA methylation using DNA isolated from stool specimens and buccal<br /><br>swabs.</p><br>